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The disease sickle cell anaemia is marked by the presence of an abnormal protein in the blood of people with this disease - VCE - SSCE Chemistry - Question 5 - 2008 - Paper 1
Question 5
The disease sickle cell anaemia is marked by the presence of an abnormal protein in the blood of people with this disease. The sixth position in the normal protein c... show full transcript
Worked Solution & Example Answer:The disease sickle cell anaemia is marked by the presence of an abnormal protein in the blood of people with this disease - VCE - SSCE Chemistry - Question 5 - 2008 - Paper 1
Step 1
molecular mass
Answer
To determine the molecular mass of the proteins, we need to analyze their composition. The sickle cell protein chain has a valine residue, which is smaller than glutamic acid in terms of molecular weight. Thus, the normal protein chain, having glutamic acid, will have a higher molecular mass. Therefore, the correct choice is:
D. Normal protein chain has the greater molecular mass.
Step 2
H NMR spectrum
Answer
In terms of $^1H NMR$ spectra, different amino acids present in the protein structure will result in differing signals. The normal protein chain will show distinct signals corresponding to glutamic acid, while the sickle cell protein will display signals different due to the presence of valine. Thus, option D is also supported since the two protein chains will have different $^1H NMR$ spectra.