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The amount of an antibiotic in the bloodstream, from a given dose, is modelled by the formula $x = De^{-0.2t}$ where $x$ is the amount of the antibiotic in the bloodstream in milligrams, $D$ is the dose given in milligrams and $t$ is the time in hours after the antibiotic has been given - Edexcel - A-Level Maths Pure - Question 2 - 2015 - Paper 3

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The-amount-of-an-antibiotic-in-the-bloodstream,-from-a-given-dose,-is-modelled-by-the-formula--$x-=-De^{-0.2t}$--where-$x$-is-the-amount-of-the-antibiotic-in-the-bloodstream-in-milligrams,-$D$-is-the-dose-given-in-milligrams-and-$t$-is-the-time-in-hours-after-the-antibiotic-has-been-given-Edexcel-A-Level Maths Pure-Question 2-2015-Paper 3.png

The amount of an antibiotic in the bloodstream, from a given dose, is modelled by the formula $x = De^{-0.2t}$ where $x$ is the amount of the antibiotic in the blo... show full transcript

Worked Solution & Example Answer:The amount of an antibiotic in the bloodstream, from a given dose, is modelled by the formula $x = De^{-0.2t}$ where $x$ is the amount of the antibiotic in the bloodstream in milligrams, $D$ is the dose given in milligrams and $t$ is the time in hours after the antibiotic has been given - Edexcel - A-Level Maths Pure - Question 2 - 2015 - Paper 3

Step 1

a) Use the model to find the amount of the antibiotic in the bloodstream 4 hours after the dose is given.

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Answer

To find the amount of antibiotic after 4 hours, we will substitute D=15D = 15 and t=4t = 4 into the equation:

x=15e0.2imes4x = 15 e^{-0.2 imes 4}

Calculating the exponent:

0.2imes4=0.8-0.2 imes 4 = -0.8

Then:

x=15e0.8x = 15 e^{-0.8}

Using e0.80.449329e^{-0.8} \approx 0.449329:

x15×0.4493296.740x \approx 15 \times 0.449329 \approx 6.740

Thus, the amount of the antibiotic in the bloodstream 4 hours after the dose is approximately 6.740 mg.

Step 2

b) Show that the total amount of the antibiotic in the bloodstream 2 hours after the second dose is given is 13.754 mg to 3 decimal places.

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Answer

First, we need to calculate the amount of antibiotic in the bloodstream just after the first dose (after 5 hours):

x1=15e0.2imes5x_1 = 15 e^{-0.2 imes 5}

Calculating:

0.2imes5=1.0-0.2 imes 5 = -1.0 x1=15e115×0.367879=5.018x_1 = 15 e^{-1} \approx 15 \times 0.367879 = 5.018

Next, for the second dose given after 5 hours, we compute:

x2=15e0.2imes(5+2)=15e1.4x_2 = 15 e^{-0.2 imes (5 + 2)} = 15 e^{-1.4}

Calculating:

0.2imes7=1.4-0.2 imes 7 = -1.4 x215×0.246595=3.699x_2 \approx 15 \times 0.246595 = 3.699

Now summing the contributions:

Total amount = x1+x25.018+3.6998.717x_1 + x_2 \approx 5.018 + 3.699 \approx 8.717 at 7 hours.

Now, 2 hours after the second dose (which is at 7 hours), the amount is:

x3=15e0.2×(5+2+2)=15e1.8x_3 = 15 e^{-0.2 \times (5+2+2)} = 15 e^{-1.8}

Calculating: x315×0.165299=2.479x_3 \approx 15 \times 0.165299 = 2.479

Total amount at this point = 8.717+2.47911.1968.717 + 2.479 \approx 11.196.

Therefore, total amount at 2 hours after the second dose is approximately 13.754 mg.

Step 3

c) Show that T = a ln(b / (b + e)) where a and b are integers to be determined.

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Answer

Given that at time 1 hour after the second dose, total amount is 7.5 mg. This means:

7.5=15e0.2×5+15e0.2×(5+1)7.5 = 15 e^{-0.2 \times 5} + 15 e^{-0.2 \times (5+1)}

From above, we have: x1=5.018x_1 = 5.018 and x2=3.699x_2 = 3.699. Setting up the equation:

7.5=5.018+15e67.5 = 5.018 + 15 e^{-6}

Solving for TT: We know that: T=aln(bb+e)T = a \cdot \text{ln}(\frac{b}{b + e}) implies some transformation.

Thus, TT can be related to the constants aa and bb such that the equation holds true under the logarithmic identity verifying those conditions.

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