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Drug Therapies Simplified Revision Notes

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12.3.1 Drug Therapies

Drug therapy: typical and atypical antipsychotics

Psychotic = a condition where a person loses touch with reality

Typical antipsychotics (first-generation antipsychotics)

Typical antipsychotics are dopamine antagonists, meaning they inhibit dopamine activity by blocking dopamine receptors in the synapse.

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Examples = chlorpromazine and haloperidol

  • Typical antipsychotics are more effective at treating the positive symptoms of schizophrenia e.g. Delusions

Atypical antipsychotics (second-generation antipsychotics)

  • Developed in the 1980s as a solution to the potentially damaging side effects of typical antipsychotics Atypical antipsychotics are dopamine antagonists but may also act as serotonin agonists, meaning they inhibit serotonin reuptake in the synapse

  • Atypical antipsychotics treat both the positive and negative symptoms of schizophrenia

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Examples = risperidone, olanzapine and clozapine

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Evaluation:

(1)

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P: A weakness of antipsychotic drugs is the severe side effects.

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E: For example, some patients on typical antipsychotics develop tardive dyskinesia- a condition where there are uncontrollable facial tics. Even after stopping the use of the drug, this condition can persist. Side effects are less severe where patients are taking a reduced dose, as many do today, but this can reduce the effectiveness of the drug as well.

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E: Therefore, The severity of the side effects is a weakness as patients will be reluctant to take them, or may experience long-term negative effects as a result of the drugs.

(2)

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P: Research shows that drug therapies are improving and becoming more effective

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E: Atypical antipsychotics are effective in 30% to 50% of treatment of resistant cases, that is, where other typical antipsychotics have failed.

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E: This suggests that drug therapies are constantly developing and improving, and also proving to be effective in treating schizophrenia.

(3)

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P: There are potential ethical issues with how drug therapies are being used

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E: Antipsychotics have been used in hospitals to calm patients and make them easier for staff to work with rather than for the patient's benefit –

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E: Therefore, perhaps other methods of treatment that work to improve the patient, such as CBT are more effective.

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