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Last Updated Sep 27, 2025
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Psychotic = a condition where a person loses touch with reality
Typical antipsychotics are dopamine antagonists, meaning they inhibit dopamine activity by blocking dopamine receptors in the synapse.
Examples = chlorpromazine and haloperidol
Developed in the 1980s as a solution to the potentially damaging side effects of typical antipsychotics Atypical antipsychotics are dopamine antagonists but may also act as serotonin agonists, meaning they inhibit serotonin reuptake in the synapse
Atypical antipsychotics treat both the positive and negative symptoms of schizophrenia
Examples = risperidone, olanzapine and clozapine
P: A weakness of antipsychotic drugs is the severe side effects.
E: For example, some patients on typical antipsychotics develop tardive dyskinesia- a condition where there are uncontrollable facial tics. Even after stopping the use of the drug, this condition can persist. Side effects are less severe where patients are taking a reduced dose, as many do today, but this can reduce the effectiveness of the drug as well.
E: Therefore, The severity of the side effects is a weakness as patients will be reluctant to take them, or may experience long-term negative effects as a result of the drugs.
P: Research shows that drug therapies are improving and becoming more effective
E: Atypical antipsychotics are effective in 30% to 50% of treatment of resistant cases, that is, where other typical antipsychotics have failed.
E: This suggests that drug therapies are constantly developing and improving, and also proving to be effective in treating schizophrenia.
P: There are potential ethical issues with how drug therapies are being used
E: Antipsychotics have been used in hospitals to calm patients and make them easier for staff to work with rather than for the patient's benefit –
E: Therefore, perhaps other methods of treatment that work to improve the patient, such as CBT are more effective.
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