Photo AI

A decrease in the activity of PISK can cause type II diabetes - AQA - A-Level Biology - Question 6 - 2021 - Paper 1

Question icon

Question 6

A-decrease-in-the-activity-of-PISK-can-cause-type-II-diabetes-AQA-A-Level Biology-Question 6-2021-Paper 1.png

A decrease in the activity of PISK can cause type II diabetes. Use Figure 5 to explain why. Myelodysplastic syndromes (MDS) are a group of malignant cancers. In MD... show full transcript

Worked Solution & Example Answer:A decrease in the activity of PISK can cause type II diabetes - AQA - A-Level Biology - Question 6 - 2021 - Paper 1

Step 1

Explain how HSCT is an effective treatment for MDS.

96%

114 rated

Answer

HSCT is effective because it replaces the faulty bone marrow, which does not produce healthy blood cells, with healthy stem cells from a donor. This allows for the production of normal blood cells, thereby reducing the symptoms and risks associated with MDS.

Step 2

Suggest and explain how AZA can reduce the effects of MDS in some patients.

99%

104 rated

Answer

AZA reduces the methylation of DNA, which can lead to the re-expression of tumor suppressor genes. This may prevent uncontrolled cell division and promote normal differentiation of blood cells.

Step 3

Give five reasons why.

96%

101 rated

Answer

  1. It provides a direct comparison of AZA with conventional treatment.
  2. The control group highlights the differences in treatment outcomes.
  3. Helps to establish the efficacy of AZA in managing MDS.
  4. Ethical considerations in the study of MDS treatment.
  5. Insights into long-term effects of different treatment methodologies.

Join the A-Level students using SimpleStudy...

97% of Students

Report Improved Results

98% of Students

Recommend to friends

100,000+

Students Supported

1 Million+

Questions answered

;