Use your knowledge of phagocytosis to describe how an ADC enters and kills the tumour cell - AQA - A-Level Biology - Question 7 - 2021 - Paper 1
Question 7
Use your knowledge of phagocytosis to describe how an ADC enters and kills the tumour cell.
Figure 8 shows how an ADC enters and kills a tumour cell.
The process o... show full transcript
Worked Solution & Example Answer:Use your knowledge of phagocytosis to describe how an ADC enters and kills the tumour cell - AQA - A-Level Biology - Question 7 - 2021 - Paper 1
Step 1
Cell ingests/engulfs the antibody/ADC
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Answer
The tumour cell recognizes the ADC and engulfs it through a process similar to endocytosis. This involves the cell membrane surrounding the ADC.
Step 2
Lysosomes fuse with the vesicle/phagosome (containing ADC)
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Once the ADC is internalized, lysosomes fuse with the phagosome that contains the ADC.
Step 3
Lysosomes break down/digest the antibody/ADC to release the drug
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The enzymes from the lysosomes break down the ADC, releasing the drug which then induces cell death.
