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Cystic fibrosis is a recessive genetic disorder - Edexcel - GCSE Biology - Question 3 - 2018 - Paper 1

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Cystic fibrosis is a recessive genetic disorder. The pedigree chart shows the inheritance of cystic fibrosis in a family. The chart indicates that: - Rob and Jane a... show full transcript

Worked Solution & Example Answer:Cystic fibrosis is a recessive genetic disorder - Edexcel - GCSE Biology - Question 3 - 2018 - Paper 1

Step 1

Explain how the pedigree chart shows that cystic fibrosis is a recessive genetic disorder.

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Answer

The pedigree chart indicates that Rob and Jane, who do not have cystic fibrosis, have a child (Leon) with the condition. This demonstrates that both parents must carry the recessive allele (heterozygous) and pass it on to their offspring for the child to express the condition. Thus, at least one child (Leon) has received two recessive alleles, confirming the recessive inheritance of cystic fibrosis.

Step 2

Which genotype is not possible for Leon?

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Answer

Leon cannot have the genotype 'FF' since it would mean he has two dominant alleles and cannot express cystic fibrosis. Therefore, a cross (✗) should be placed next to option B.

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