Biological: Genetic Explanation (AQA A-Level Psychology): Flashcards
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Genetic explanation of schizophrenia
Genetic explanation of schizophrenia
Transmitted via genes; multiple genes increase vulnerability
Polygenic inheritance in schizophrenia
Polygenic inheritance in schizophrenia
Multiple genes contribute to risk, not one single gene
Gottesman & Shields (1976) MZ twin concordance (severe cases)
Gottesman & Shields (1976) MZ twin concordance (severe cases)
75-91%
Torrey et al. (1994) identical twin concordance rate
Torrey et al. (1994) identical twin concordance rate
28%
Kety & Ingraham (1992) genetic vs adoptive relatives
Kety & Ingraham (1992) genetic vs adoptive relatives
10x higher prevalence in genetic relatives
Gurling et al. (2006) chromosome & gene identified
Gurling et al. (2006) chromosome & gene identified
Chromosome 8p21-22; PCMI gene
Schizophrenia Working Group (2014) genetic variations found
Schizophrenia Working Group (2014) genetic variations found
128 variations at 108 chromosome locations
Why MZ twin concordance <100% matters
Why MZ twin concordance <100% matters
Shows environmental factors important, not purely genetic
Diathesis-stress model
Diathesis-stress model
Genetic predisposition + environmental triggers = disorder
Gene-environment interaction in schizophrenia
Gene-environment interaction in schizophrenia
Genetic predisposition may require environmental triggers