Epistasis (AQA A-Level Biology): Flashcards

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Epistasis
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What is epistasis?

One gene masks/modifies another gene's expression

In mice, which gene is epistatic to Gene A?

Gene B

What does Gene A control in mouse coat colour?

Melanin distribution pattern

What does Gene B control in mouse coat colour?

Melanin production

Phenotype of bb genotype in mice

White (albino) coat

F2 ratio in mouse epistasis cross

9:4:3

What does 9:4:3 ratio indicate?

Epistatic interaction, not independent assortment

Phenotype of A_B_ genotype in mice

Agouti (grey-brown)

Phenotype of aaB_ genotype in mice

Black

Requirement for biochemical pathway in epistasis

Both enzymes must be functional

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