Carlsson et al. (2000) Network Interactions in Schizophrenia (Edexcel A-Level Psychology): Flashcards

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Carlsson et al. (2000) Network Interactions in Schizophrenia
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Prize Carlsson won in 2000

Nobel Prize in Physiology or Medicine

Hyperdopaminergia theory

Elevated dopamine levels cause schizophrenia symptoms

Hypoglutamatergia theory

Reduced glutamate levels contribute to schizophrenia

PCP's effect on receptors

Antagonist of NMDA receptors (blocks glutamate)

When glutamate decreases, dopamine...

Increases

Cerebral cortex glutamate failure causes

Negative symptoms of schizophrenia

Basal ganglia glutamate failure causes

Positive symptoms of schizophrenia

Clozapine's dual action properties

Antidopaminergic and antiserotonerergic

Glutamate's function in brain

Activates neurones and enables neural transmission

Carlsson et al. main conclusion

Schizophrenia may have different subtypes with varied causes

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