Producing Monoclonal Antibodies (OCR GCSE Biology A (Gateway Science Suite)): Flashcards
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What are monoclonal antibodies?
What are monoclonal antibodies?
Identical antibodies produced from the same immune cell
What do monoclonal antibodies bind to?
What do monoclonal antibodies bind to?
Only one specific protein antigen
Give an example use of monoclonal antibodies
Give an example use of monoclonal antibodies
Pregnancy testing
What is the first cell type used to produce monoclonal antibodies?
What is the first cell type used to produce monoclonal antibodies?
Mice lymphocytes (make antibodies but cannot divide)
Can lymphocytes divide?
Can lymphocytes divide?
No, cannot divide
What do lymphocytes produce?
What do lymphocytes produce?
A specific antibody
What is the second cell type used in monoclonal antibody production?
What is the second cell type used in monoclonal antibody production?
Tumour cells
How do tumour cells divide?
How do tumour cells divide?
Divide rapidly
Do tumour cells make antibodies?
Do tumour cells make antibodies?
No, do not make antibodies
What cell is formed when lymphocytes and tumour cells are combined?
What cell is formed when lymphocytes and tumour cells are combined?
Hybridoma
What does a hybridoma produce when it divides?
What does a hybridoma produce when it divides?
Clones of itself that produce the same antibody
What is the final step in monoclonal antibody production?
What is the final step in monoclonal antibody production?
Antibodies are collected and purified