Evaluation of DNA Technology (AQA A-Level Biology): Flashcards
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What is epigenetics?
What is epigenetics?
Heritable changes in gene expression without altering DNA sequence
Why does fetal haemoglobin help in sickle cell disease?
Why does fetal haemoglobin help in sickle cell disease?
Greater oxygen affinity, prevents sickling of red blood cells
Gene therapy strategy for sickle cell disease
Gene therapy strategy for sickle cell disease
Reactivate fetal haemoglobin production
Effect of decreased histone acetylation
Effect of decreased histone acetylation
Tighter DNA packaging, genes inaccessible and switched off
Effect of increased DNA methylation
Effect of increased DNA methylation
Inhibits gene expression by preventing transcription factor binding
Epigenome function
Epigenome function
Cellular memory system accumulating environmental signals
What does chromatin structure affect?
What does chromatin structure affect?
Gene accessibility for transcription
Environmental factors influencing gene expression
Environmental factors influencing gene expression
Diet, stress levels, exposure to toxins
Advantage of gene therapy approach
Advantage of gene therapy approach
Works with natural regulatory mechanisms
Challenge of DNA technology
Challenge of DNA technology
Environmental factors unpredictably influence gene expression