Evaluation of DNA Technology (AQA A-Level Biology): Quizzes

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Evaluation of DNA Technology
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What strategy does gene therapy use for sickle cell disease based on fetal haemoglobin research?

Reactivating fetal haemoglobin production

What is epigenetics?

Heritable changes in gene expression

Why does fetal haemoglobin reduce sickle cell disease symptoms?

It has greater oxygen affinity

What happens when histone acetylation decreases?

DNA packaging tightens, genes switch off

What effect does increased DNA methylation typically have?

Inhibits gene expression

What function does the epigenome serve in cells?

A cellular memory system

Which environmental factors can modify gene expression?

Diet, stress levels, and toxin exposure

What challenge do therapeutic genes face after introduction through gene therapy?

They must integrate with chromatin structures

What is an advantage of DNA technology approaches?

They work with natural regulatory mechanisms

What limitation affects DNA technology outcomes?

Environmental factors unpredictably influence outcomes

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