Scott-Van Zeeland et al. (2013) Role of EPHX2 Gene Variants in Anorexia Nervosa (Edexcel A-Level Psychology): Flashcards
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No. of candidate genes studied in Scott-Van Zeeland et al. (2013)
No. of candidate genes studied in Scott-Van Zeeland et al. (2013)
152 genes
Most significant gene linked to anorexia in the study
Most significant gene linked to anorexia in the study
EPHX2 gene
Role of EPHX2 gene in the body
Role of EPHX2 gene in the body
Cholesterol metabolism
Brain region with high EPHX2 expression
Brain region with high EPHX2 expression
Paraventricular nucleus of the thalamus
Initial sample size in Scott-Van Zeeland study
Initial sample size in Scott-Van Zeeland study
261 AN patients + 73 controls (all female)
Traits of AN patients with EPHX2 variants
Traits of AN patients with EPHX2 variants
Highest depression scores & lowest BMI
Two-phase approach in the study
Two-phase approach in the study
Initial sequencing then in-depth analysis
Tool used to measure depression in the study
Tool used to measure depression in the study
Beck's Depression Inventory
Key weakness re: sample composition
Key weakness re: sample composition
Female-only initial sample limits generalisability to males
Source of extended DNA samples (500 AN + 500 controls)
Source of extended DNA samples (500 AN + 500 controls)
Price Foundation sample repository