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10 cards from this deck
Heritable changes in gene function without altering DNA sequence
Chemical modifications on DNA & histones determining gene access
Loosely packed chromatin, DNA accessible, genes switched on
Tightly packed chromatin, DNA inaccessible, genes switched off
Histones more +ve charged, stronger DNA attraction, genes inhibited
Methyl groups (extCH3 ext{CH}_3extCH3) to cytosine bases in DNA
Blocks transcription factors; attracts deacetylation proteins
Abnormal patterns activate oncogenes or silence tumour suppressors
Demethylating drugs & histone deacetylase inhibitors
Uses siRNA to break down specific mRNA before translation
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