Immunotherapy (VCE SSCE Biology): Flashcards

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Immunotherapy
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Immunotherapy

Modulates immune system functioning to treat disease

Two immunotherapy categories

Activation (boost) and suppression (reduce)

Monoclonal antibodies (mAbs)

Identical lab-made antibodies from plasma cell clones

Hybridoma

Fusion of B lymphocyte and myeloma cell

ADCC mechanism

mAbs mark cancer cells; NK cells destroy them

Conjugated mAbs

mAbs with toxic molecules attached (drugs/isotopes)

Apoptosis

Programmed cell death

Autoimmune disease

Immune system attacks own cells

Immunosuppression

Reduced immune system ability to respond

CAR-T therapy

T cells modified with chimeric antigen receptors

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