Buffers and Neutralisation (OCR A-Level Chemistry A): Flashcards

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Buffer solutions in the body
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Blood plasma pH range for proper function

7.35 to 7.45

Normal healthy blood pH

7.40

Primary buffer system in blood plasma

Carbonic acid-hydrogencarbonate buffer system

Medical condition when blood pH < 7.35

Acidosis

Medical condition when blood pH > 7.45

Alkalosis

Equilibrium for blood's main buffer

H2CO3H++HCO3\text{H}_2\text{CO}_3 \rightleftharpoons \text{H}^+ + \text{HCO}_3^-

pKa\text{p}K_\text{a} of carbonic acid at body temp

6.1

Ratio [HCO3]:[H2CO3][\text{HCO}_3^-]:[\text{H}_2\text{CO}_3] in healthy blood

20:1

How body removes excess carbonic acid

Converts to CO2\text{CO}_2 gas, exhaled through lungs

Henderson-Hasselbalch equation

pH=pKa+log([A]/[HA])\text{pH} = \text{p}K_\text{a} + \log([A^-]/[HA])

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