DNA Replication, Protein Synthesis, and Mutations (LC 2027) (Leaving Cert Biology): Flashcards

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DNA Replication, Protein Synthesis, and Mutations
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Central dogma of molecular biology

DNA → RNA → Protein

Transcription

DNA to mRNA conversion in nucleus

RNA polymerase role

Enzyme that reads DNA & builds complementary mRNA

RNA base replacing thymine

Uracil (U)

Translation

mRNA to protein conversion at ribosomes

Codon

Group of 3 bases on mRNA specifying amino acid

Start codon

AUG

mRNA function

Carries genetic info from nucleus to ribosomes

tRNA function

Delivers amino acids using anticodon matching

rRNA function

Forms ribosome structure with proteins

Mutation

Sudden change in amount or structure of DNA

Mutagens

External agents that increase mutation rate

Point mutation

Change in single gene affecting few DNA bases

Chromosomal mutation

Large-scale changes affecting entire chromosomes

Down syndrome chromosome number

47 (extra chromosome 21)

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