Optical Isomers and Inhibition of Enzymes (VCE SSCE Chemistry): Quizzes

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Optical Isomers and Inhibition of Enzymes
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What are optical isomers also called?

Enantiomers

Which form of ascorbic acid (vitamin C\text{C}) prevents scurvy?

L-ascorbic acid

What does the term 'chiral' mean?

Mirror images that can't be superimposed

What defines a chiral centre in an organic molecule?

Carbon bonded to 4 different groups

Which carbon-containing group cannot be a chiral centre?

CH3-\text{CH}_3 groups

What percentage of drugs in use contain chiral molecules?

56%

What are the different effects of propoxyphene enantiomers?

D-form relieves pain; L-form relieves cough

Which thalidomide enantiomer causes birth defects?

S-enantiomer

How do competitive enzyme inhibitors work?

Occupy the active site

How do non-competitive inhibitors affect enzymes?

Bind elsewhere and change enzyme shape

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