Optical Isomers and Inhibition of Enzymes (VCE SSCE Chemistry): Flashcards
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Optical isomers (enantiomers)
Optical isomers (enantiomers)
Same formula, diff 3D arrangement, non-superimposable mirror images
Chiral objects
Chiral objects
Mirror images that cannot be superimposed
Chiral centre in organic molecules
Chiral centre in organic molecules
Carbon bonded to 4 different groups in tetrahedral shape
Achiral objects property
Achiral objects property
Mirror images can be superimposed; have plane of symmetry
% of drugs containing chiral molecules
% of drugs containing chiral molecules
56%
More effective ibuprofen enantiomer
More effective ibuprofen enantiomer
S-ibuprofen (better at reducing pain & inflammation)
Thalidomide R-enantiomer effect
Thalidomide R-enantiomer effect
Treats morning sickness effectively (safe)
Competitive enzyme inhibitor mechanism
Competitive enzyme inhibitor mechanism
Occupies active site, competes with substrate
Non-competitive inhibitor mechanism
Non-competitive inhibitor mechanism
Binds elsewhere on enzyme, changes shape of active site
Penicillin inhibition type & target
Penicillin inhibition type & target
Competitive inhibitor of transpeptidase in bacterial cell walls