Cellular Control (OCR A-Level Biology A): Flashcards

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Body Plan Development
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Transcription factors

Proteins binding DNA, controlling gene transcription rate

Homeobox sequence: bases & amino acids coded

180 bases coding for 60 amino acids

Antennapedia mutation effect in Drosophila

Legs grow in place of antennae on head

What Hox genes control

Body plan along head-tail axis; regulate other genes

Number of Hox clusters in vertebrates

4 clusters

Hox gene order principle

Linear gene order = body region order they affect

Apoptosis

Programmed cell death

Proto-oncogenes function

Stimulate cell division

Tumour-suppressor genes function

Reduce cell division, stimulate apoptosis in damaged cells

Cyclins vs CDKs roles

Cyclins = regulators; CDKs = catalysts when activated

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