Proteins: Enzymes (AQA A-Level Biology): Quizzes

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The Induced-Fit Model
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What does the induced-fit model describe?

Dynamic enzyme-substrate interaction

In the induced-fit model, is the active site initially complementary to the substrate?

No, not complementary

What happens during the conformational change stage?

Active site moulds around substrate

What analogy is used to explain the induced-fit model?

Sock and foot

How does the lock-and-key model differ from the induced-fit model?

Lock-and-key has rigid active site

What reaction does hexokinase catalyse?

Glucose+ATPGlucose 6-phosphate+ADP\text{Glucose} + \text{ATP} \to \text{Glucose 6-phosphate} + \text{ADP}

What technique was used to study hexokinase's shape changes?

X-ray diffraction

What did X-ray diffraction reveal about hexokinase binding?

Active site changed shape significantly

How does the induced-fit model explain catalytic efficiency?

Shape change optimises positioning

Why is the induced-fit model now favoured?

It better explains observations

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