The Induced-Fit Model (AQA A-Level Biology): Flashcards
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What is the induced-fit model?
What is the induced-fit model?
Model where enzyme active site changes shape to fit substrate
Is active site initially complementary to substrate?
Is active site initially complementary to substrate?
No, not initially complementary
What happens to active site when substrate binds?
What happens to active site when substrate binds?
Changes shape, moulds around substrate
Result of improved enzyme-substrate fit
Result of improved enzyme-substrate fit
Stable enzyme-substrate complex
Analogy for induced-fit model
Analogy for induced-fit model
Sock moulding around foot
Lock-and-key model active site
Lock-and-key model active site
Rigid and unchanging
Induced-fit model active site
Induced-fit model active site
Flexible and dynamic
Enzyme evidence for induced-fit model
Enzyme evidence for induced-fit model
Hexokinase
Technique to study enzyme shape changes
Technique to study enzyme shape changes
X-ray diffraction
Hexokinase X-ray diffraction finding
Hexokinase X-ray diffraction finding
Active site changed shape when glucose bound