Anticancer Drugs (AQA A-Level Chemistry): Flashcards

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Chemical formula of cisplatin

[PtCl2(NH3)2][PtCl_2(NH_3)_2]

Geometry of cisplatin

Square planar

Configuration of cisplatin

Cis (chloride ions adjacent)

How does cisplatin prevent DNA replication?

Ligand replacement reaction

Which DNA base does cisplatin bind to?

Guanine

What replaces Cl−Cl^- in cisplatin inside the cell?

Water molecules (H2OH_2O) - aquation

How many guanine bases does cisplatin bind to?

Two adjacent guanine bases

Side effects of cisplatin

Hair loss, nausea, fatigue, increased infection risk

Which cancers does cisplatin treat?

Testicular, ovarian, cervical, lung, brain

Why is cisplatin still used despite side effects?

Long-term positive effects outweigh short-term negative

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Amines (A Level only)

Polymers (A Level only)

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