Anticancer Drugs (AQA A-Level Chemistry): Quizzes
📚Quizzes
Practise the questions
10 questions from this quiz
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Practise the questions
10 questions from this quiz
What is the geometry of the cisplatin complex?
What is the geometry of the cisplatin complex?
Square planar
What is the chemical formula of cisplatin?
What is the chemical formula of cisplatin?
Why is the cis configuration essential for cisplatin's therapeutic action?
Why is the cis configuration essential for cisplatin's therapeutic action?
Allows DNA cross-linking
What process occurs when ions in cisplatin are replaced by inside the cell?
What process occurs when ions in cisplatin are replaced by inside the cell?
Aquation
Which DNA base does cisplatin specifically bind to?
Which DNA base does cisplatin specifically bind to?
Guanine
What type of bond forms between cisplatin's platinum and the nitrogen atom on guanine?
What type of bond forms between cisplatin's platinum and the nitrogen atom on guanine?
Dative covalent bond
How many adjacent guanine bases does cisplatin typically bind to?
How many adjacent guanine bases does cisplatin typically bind to?
Two
How does cisplatin prevent DNA replication?
How does cisplatin prevent DNA replication?
Prevents DNA strands unwinding
Which healthy cells are most affected by cisplatin?
Which healthy cells are most affected by cisplatin?
Rapidly dividing cells
How can cisplatin's side effects be reduced?
How can cisplatin's side effects be reduced?
Very low doses or direct targeting