Organic Synthesis (OCR A-Level Chemistry A): Flashcards

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Carbon–Carbon Bond Formation
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Structure of nitrile functional group

CN-\text{C}\equiv\text{N}

Reagent to convert haloalkanes to nitriles

NaCN\text{NaCN} or KCN\text{KCN} in ethanol

Mechanism type: haloalkanes to nitriles

Nucleophilic substitution (SN2\text{S}_\text{N}2)

Product name: aldehyde/ketone + HCN

Hydroxynitrile (or cyanohydrin)

Reagent to reduce nitriles to primary amines

H2\text{H}_2 with Ni catalyst

Product from hydrolysis of nitriles

Carboxylic acids

Catalyst for Friedel-Crafts reactions

Aluminium chloride (AlCl3\text{AlCl}_3)

Product type from Friedel-Crafts acylation

Ketone

General formula of Grignard reagents

R-MgX\text{R-MgX} (R = alkyl/aryl, X = halogen)

Solvent condition for Grignard preparation

Dry (anhydrous) ether

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